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Antigenic Specificity | MKNK1 (N-term), 1-30 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MKNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MKNK1. MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence.C-terminal region of MKNK1 was phosphorylated and activated in vivo and in vitro by ERK1 and p38 MAP kinases, but not by JNK/SAPK. The activated ERK is essential for the activation of MKNK1 in insect cells. MKNK1 was activated following stimulation of HeLa cells with a variety of extracellular stimuli. MNK1 bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2, and also bi |
Immunogen | n/a |
Other Names | [MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1; MKNK1; MNK1] |
Gene, Accession # | [MKNK1], Gene ID: 8569, NCBI: NP_001129025.1, UniProt: Q9BUB5 |
Catalog # | MBS9203656 |
Price | $165, $370 |
Order / More Info | MKNK1 (N-term), 1-30 Antibody from MYBIOSOURCE INC. |
Product Specific References | Orton, K.C., et al., J. Biol. Chem. 279(37):38649-38657 (2004). Cuesta, R., et al., J. Virol. 78(14):7707-7716 (2004). Knauf, U., et al., Mol. Cell. Biol. 21(16):5500-5511 (2001). Cuesta, R., et al., Genes Dev. 14(12):1460-1470 (2000). Fukunaga, R., et al., EMBO J. 16(8):1921-1933 (1997). |