Edit |   |
---|---|
Antigenic Specificity | MME (Center) |
Clone | [965CT9.1.1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1,k |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MME antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 472-505 amino acids from the Central region of human MME. Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met-and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). |
Immunogen | n/a |
Other Names | [Neprilysin; 3.4.24.11; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10; MME; EPN] |
Gene, Accession # | [MME], Gene ID: 4311, NCBI: NP_000893.2, UniProt: P08473 |
Catalog # | MBS9230971 |
Price | $165, $370 |
Order / More Info | MME (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | Letarte M.,et al.J. Exp. Med. 168:1247-1253 (1988). Shipp M.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4819-4823 (1988). D'Adamio L.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:7103-7107 (1989). Ota T.,et al.Nat. Genet. 36:40-45 (2004). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. |