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Antigenic Specificity | CAS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Immunofluorescence (IF), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CAS Polyclonal Antibody detects endogenous levels of CAS protein. Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein (chromosome segregation 1 like) may play a role both in apoptosis and in |
Immunogen | Immunogen: Synthesized peptide derived from the N-terminal region of human CAS at AA range: 1-80 |
Other Names | [Rabbit CAS; CSE1L; CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter] |
Gene, Accession # | [CAS], Gene ID: 1434, NCBI: NP_001243064.1, UniProt: P55060 |
Catalog # | MBS9701573 |
Price | $130, $220, $325 |
Order / More Info | CAS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |