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Antigenic Specificity | Phospho-EIF4EBP1 (S111) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse, rat) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.29 |
Applications | Dot Blot (DB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This EIF4EBP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S111 of human EIF4EBP1. EIF4EBP1 is a member of a family of translation repressor proteins. This protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of EIF4EBP1 with eIF4E inhibits complex assembly and represses translation. EIF4EBP1 is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. |
Immunogen | n/a |
Other Names | [Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I; EIF4EBP1] |
Gene, Accession # | [EIF4EBP1], Gene ID: 1978, NCBI: NP_004086.1, UniProt: Q13541 |
Catalog # | MBS9210664 |
Price | $165, $370 |
Order / More Info | Phospho-EIF4EBP1 (S111) Antibody from MYBIOSOURCE INC. |
Product Specific References | Fonseca,B.D., J. Biol. Chem. 282 (34), 24514-24524 (2007) Armengol,G., Cancer Res. 67 (16), 7551-7555 (2007) |