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Antigenic Specificity | TSC2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. |
Immunogen | Immunogen: Recombinant human Tuberin protein (1396-1496AA) |
Other Names | [Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4] |
Gene, Accession # | [TSC2], Gene ID: 7249, NCBI: NP_000539.2, UniProt: P49815 |
Catalog # | MBS7049875 |
Price | $160, $235 |
Order / More Info | TSC2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |