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Antigenic Specificity | EIF4EBP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity (2, 3). Multiple 4E-BP1 residues are phosphorylated in vivo (4). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70 (5). |
Immunogen | Immunogen: Recombinant protein of human EIF4EBP1 Observed Molecular Weight: 12kDa |
Other Names | [EIF4EBP1; 4E-BP1; 4EBP1; BP-1; MGC4316; PHAS-I] |
Gene, Accession # | [EIF4EBP1], Gene ID: 1978, NCBI: CAG33050.1, UniProt: Q13541 |
Catalog # | MBS2526321 |
Price | $150, $225, $360 |
Order / More Info | EIF4EBP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |