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Antigenic Specificity | Tubulin beta |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and beta-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8.1 Mutant huntingtin, disrupted intracellular transport and insulin secretion by direct interference with microtubular beta-tubulin. Mutant huntingtin impaired glucose-stimulated insulin secretion in insulin-producing beta cells, without altering stored levels of insulin. Smith et al. (2009) proposed a novel pathogenetic process by which mutant |
Immunogen | Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of human Tubulin b. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS355105 |
Price | $275 |
Order / More Info | Tubulin beta Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Williams RC Jr, Shah C, Sackett D (November 1999). Separation of tubulin isoforms by isoelectric focusing in immobilized pH gradient gels. Anal Biochem 275 (2): 265-7. 2. Smith, R., Bacos, K., Fedele, V., Soulet, D., Walz, H. A., Obermuller, S., Lindqvist, A., Bjorkqvist, M., Klein, P., Onnerfjord, P., Brundin, P., Mulder, H., Li, J.-Y. Mutant huntingtin interacts with beta-tubulin and disrupts vesicular transport and insulin secretion. Hum. Molec. Genet. 18: 3942-3954, 2009. |