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Antigenic Specificity | TNFSF11 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total TNFSF11 protein. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regula |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human TNFSF11. |
Other Names | [ODF; OPGL; sOdf; CD254; OPTB2] |
Gene, Accession # | [TNFSF11], Gene ID: 8600, NCBI: NP_003692.1, UniProt: O14788 |
Catalog # | MBS9408272 |
Price | $255 |
Order / More Info | TNFSF11 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |