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Antigenic Specificity | CASP9 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family (1, 2). Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response (3-6). Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis (7-10). |
Immunogen | Immunogen: Recombinant protein of human CASP9 Observed Molecular Weight: 46kDa |
Other Names | [MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6] |
Gene, Accession # | [CASP9], Gene ID: 842, NCBI: P55211.3 |
Catalog # | MBS2528313 |
Price | $150, $225, $360 |
Order / More Info | CASP9 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |