TLR4, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TLR4, Human |
| Clone | HTA125 |
| Host Species | Mouse |
| Reactive Species | reactivity: human. cross reactivity: dog, monkey |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), FS, Immunoassay (IA), Immunofluorescence (IF), Immunoprecipitation (IP), Westen Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called ?pathogen-associated molecular patterns. Activation of TLRs, a family of at least 11 different members that function either as homo- or heterodimers, leads to activation of NF degree B-dependent and IFN-regulatory factor-dependent signaling pathways. TLRs have a central role in innate immunity and are also required for the development of an adaptive immune response. TLRs are expressed by various ce |
| Immunogen | Immunogen: BALB/c mice were immunized with the Ba/F3 line expressing TLR4. |
| Other Names | [TLR4, CD284, ARMD10], [TLR4] |
| Gene, Accession # | [TLR4], NCBI: ACX37356.1 |
| Catalog # | MBS584009 |
| Price | $420 |
| Order / More Info | TLR4, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Shimazu, R et al; MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999, 189: 1777 2. Tabeta, K et al; Toll-like receptors confer responsiveness to lipopolysaccharide from porphyromonas gingivalis in human gingival fibroblasts. Infect Immun 2000, 68: 3731 3. Akashi, S et al; Regulatory roles for CD14 and phosphatidylinositol in the signaling via Toll-like receptor 4-MD-2. Biochem Biophys Res Commun 2000, 268: 172 4. Wang, J et al; Involvement of CD14 and Toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect Immun 2001, 69: 2402 5. Walton, K et al; Receptors involved in the oxidized 1-palmitoyl-2 arachidonoyl-sn-glycero-3- phosphorylcholine-mediated synthesis of interleukin-8. J Biol Chem 2003, 278: 29661 6. Triantafilou, M et al; Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane. J Cell Sci 2004, 117: 4007 7. Elner, S et al; TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression. Trans Am Ophthalmol Soc 2005, 103: 126 8. Burgener, I et al; Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol 2008, 124: 184 9. Brll, F et al; TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols. J Biol Chem 2010, 285: 2951 |
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MYBIOSOURCE INC.
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