PKN beta (C-term), 463-492 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | PKN beta (C-term), 463-492 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 1.93 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This PKN beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human PKN beta. PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K. |
| Immunogen | n/a |
| Other Names | [Serine/threonine-protein kinase N3; Protein kinase PKN-beta; Protein-kinase C-related kinase 3; PKN3; PKNBETA] |
| Gene, Accession # | [PKN3], Gene ID: 29941, NCBI: NP_037487.2, UniProt: Q6P5Z2 |
| Catalog # | MBS9206722 |
| Price | $165, $370 |
| Order / More Info | PKN beta (C-term), 463-492 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Oishi, K., et al., Biochem. Biophys. Res. Commun. 261(3):808-814 (1999). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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