GSK-3alpha/beta (Tyr-279/Tyr-216), phosphospecific Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | GSK-3alpha/beta (Tyr-279/Tyr-216), phosphospecific |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, rat, mouse |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody detects 46/50 kDa* proteins corresponding to the apparent molecular mass of GSK-3b and GSK-3a on SDS-PAGE immunoblots of pervanadate treated rabbit fibroblasts, as well as treated human SKN-SH and A431 cells. Glycogen synthase kinase-3 (GSK-3) has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control, and oncogenesis. Two GSK-3 genes (alpha and beta) have been cloned in mammals and these kinase homologues show strong sequence conservation within their catalytic domain. GSK-3beta plays a critical role in cell survival by phosphorylating nuclear factor-kappa-B (NF- kappa-B) p65 subunit, leading to NF-kappa-B transactivation in hepatocytes. Phosphorylation regulates the |
| Immunogen | Immunogen: Clone M132 was generated from a phospho-GSK-3b (Tyr-216) synthetic peptide (coupled to KLH) corresponding to amino acid residues aroundtyrosine 216 of human GSK-3b. This peptide sequence is also found in GSK-3a (Tyr-279) and is highly conserved in GSK-3 genes in rat and mouse. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS470015 |
| Price | $385 |
| Order / More Info | GSK-3alpha/beta (Tyr-279/Tyr-216), phosphospecific Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Hagen, T. et al. (2002) J Biol Chem. 277(26):23330.• Takahashi-Yanaga, F. et al. (2004) Biochem Biophys Res Commun. 316(2):411.• Xinbo, L. et al. (2003) Mol Cancer Ther. 2:1215.• Ding, Y. et al. (2008) J Neurosci. 28(45):11622. (WB: Mouse cortex, hippocampus) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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