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Antigenic Specificity | AAK1 (N-term), 186-216 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: bovine, porcine) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This AAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-216 amino acids from the N-terminal region of human AAK1. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 is a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. |
Immunogen | n/a |
Other Names | [AP2-associated protein kinase 1; Adaptor-associated kinase 1; AAK1; KIAA1048] |
Gene, Accession # | [AAK1], Gene ID: 22848, NCBI: NP_055726.3, UniProt: Q2M2I8 |
Catalog # | MBS9212426 |
Price | $165, $370 |
Order / More Info | AAK1 (N-term), 186-216 Antibody from MYBIOSOURCE INC. |
Product Specific References | Henderson,D.M., Mol. Biol. Cell 18 (7), 2698-2706 (2007) Takahashi,T., Cancer Res. 66 (24), 11932-11937 (2006) Schmid,E.M., PLoS Biol. 4 (9), E262 (2006) |