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Antigenic Specificity | Integrin beta4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Integrin beta4 antibody detects endogenous levels of total Integrin beta4. Description: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.Function: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds |
Immunogen | Immunogen: A synthesized peptide derived from human Integrin beta4 Subcellular Location: Membrane. Tissue Specificity: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Chicken Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Chicken (83%) |
Other Names | [CD 104; CD104; CD104 antigen; gp150; Integrin beta 4 subunit; Integrin beta-4; ITB4_HUMAN; ITG B4; ITGB 4; Itgb4] |
Gene, Accession # | [ITGB4], Gene ID: 3691, NCBI: NP_000204.3, UniProt: P16144 |
Catalog # | MBS9601518 |
Price | $240, $280 |
Order / More Info | Integrin beta4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |