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Antigenic Specificity | Human CD40 |
Clone | [3A8] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.025 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis. |
Immunogen | n/a |
Other Names | [Human CD40; Tumor necrosis factor receptor superfamily member 5; Cd40; B-cell surface antigen CD40; Bp50; CD40L receptor; CD40; Tnfrsf5] |
Gene, Accession # | [CD40], Gene ID: 958, NCBI: NP_001241.1, UniProt: P25942 |
Catalog # | MBS2553807 |
Price | $85, $145 |
Order / More Info | Human CD40 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Banchereau J, et al. 1994. Annu. Rev. Immunol. 12:881. 2. Foy T, et al. 1996. Annu. Rev. Immunol. 14:591. |