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Antigenic Specificity | Hrs (HGS) |
Clone | [19-5] |
Host Species | Mouse |
Reactive Species | human, mouse, rat, monkey |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.05 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody recognizes an epitope is located between the VHS and coiled-coil domain of the HRS protein. Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS, also known as HGS) is a mammalian protein predominantly localized on early endosomes. Hrs interacts with many proteins involved in membrane trafficking, such as eps15, SfdMdlSNAP-25. Hrs is implicated in early endosome fusion and may play a role in cargo sorting/trafficking to early and late endosome by recruiting clathrin. Hrs is also involved in intracellular signal transduction mediated by cytokines and growth factors. |
Immunogen | Immunogen: Full length hrs-2 fusion protein |
Other Names | n/a |
Gene, Accession # | [HRS] |
Catalog # | MBS588094 |
Price | $415 |
Order / More Info | Hrs (HGS) Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Ronning SB-CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor. 2. Pullan L-The endosome-associated protein Hrs is hexameric and controls cargo sorting as a master molecule. 3. Tsujimoto S-The cellular and developmental expression of hrs-2 in rat. |