Mouse CD80/B7-1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Mouse CD80/B7-1 |
| Clone | [1G10] |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a kappa |
| Format | unconjugated |
| Size | 0.5 mg |
| Concentration | n/a |
| Applications | Flow Cytometry; Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Mouse CD80 (B7-1), Mr 45-47 kDa. CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL- 4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours postactivation. ^1-4 The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex.^5, 6 The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80, but it does not blo |
| Immunogen | n/a |
| Other Names | [Rat Mouse CD80/B7-1 - Purified, Unlabeled; Rat Mouse CD80/B7-1], [LOC554317] |
| Gene, Accession # | Gene ID: 554317, NCBI: NP_001020134.1 |
| Catalog # | MBS673443 |
| Price | $260 |
| Order / More Info | Mouse CD80/B7-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nabavi, N., G. J. Freeman, A. Gault, D. Godfrey, L. M. Nadler, and L. H. Glimcher. 1992. Nature 360:2662. Chen, C., D. A. Faherty, A. Gault, S. E. Connaughton, G. D. Powers, D. I. Godfrey, and N. Nabavi. 1996. J. Immunol. 152:2105.3. Natesan, M., Z. Razi-Wolf, and H. Reiser. 1996. J. Immunol. 156:2783.4. Razi-Wolf, Z., G. J. Freeman, F. Galvin, B. Benacerraf, L. Nadler, and H. Reiser. 1992. Proc. Natl. Acad. Sci. U. S. A. 89:4210.5. Hathcock, K. S., G. Laszlo, C. Pucillo, P. Linsley, and R. J. Hodes. 1994. J. Exp. Med. 180:631.6. Bluestone, J.A. 1995. Immunity 2:255.7. Powers, G. D., D. A. Faherty, S. E. Connaughton, D. A. Biondi, D. I. Godfrey, A. Gault, C. Y. Chen, and N. Nabavi. 1994. Cell Immunol. 153:298. |
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