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Antigenic Specificity | Alpha-Tubulin Cleaved By Caspase-6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | bovine, mouse, human |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody recognizes the sequence (EEVGVD) in tubulin protein. It is specific for Caspase 6 cleaved a-Tubulin. The antibody was tested in IHC and western blots of samples with Alzheimer disease (AD) (Bovine brain sample, human samples, cells lines, mice hippocampus and whole brains). When tested in null mice with IHC and WB, no immunoreactivity was observed. Tubulin is the major constituent of microtubules. Microtubules are assembled from dimers of a-and p-tubulin. a-Tubulin cleaved by caspase-6 can be found in neurons, neurofibrillary tangles, neutrophil threads, and neuritic plaques in Alzheimer disease. a-Tubulin has been found to associate with the axonal microtubule-associated protein Tau, indicating that the cleavage of the functio |
Immunogen | Immunogen: EEVGVD peptide |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS588220 |
Price | $435 |
Order / More Info | Alpha-Tubulin Cleaved By Caspase-6 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Klaiman G-Targets of caspase-6 activity in human neurons and Alzheimer disease. |