USP1 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-USP1 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | USP1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzymes (DUB) action (1, 2). There are five DUB subfamilies including the USP, UCH, OTU, MJD, and JAMM enzymes. USP1 belongs to the USP subfamily and is regulated in a cell cycle dependent manner by both transcriptional and ubiquitin-proteosomal mechanisms (3). USP1 is a nuclear protein and localizes to chromatin where it is specifically associated with FANCD2. USP1 deubiquitinates monoubiquitinated FANCD2, which plays an important role in DNA damage repair and Chk1 protein stability (3, 4). Another important target of USP1 is PCNA. USP1 deubiquitinates monoubiquitinated PCNA, thereby negatively regulating PCNA-mediated transles |
| Immunogen | Immunogen: Fusion protein of human USP1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [USP1; UBP] |
| Gene, Accession # | [USP1], Gene ID: 7398, NCBI: NP_001017415.1, UniProt: O94782 |
| Catalog # | MBS8527377 |
| Price | $310 |
| Order / More Info | USP1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nijman, S.M. et al. (2005) Cell 123, 773-86. 2. Nalepa, G. et al. (2006) Nat Rev Drug Discov 5, 596-613. 3. Nijman, S.M. et al. (2005) Mol Cell 17, 331-9. 4. Guervilly, J.H. et al. (2011) Hum Mol Genet, . 5. Huang, T.T. et al. (2006) Nat Cell Biol 8, 339-47. 6. Cohn, M.A. et al. (2007) Mol Cell 28, 786-97. 7. Cohn, M.A. et al. (2009) J Biol Chem 284, 5343-51. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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