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Antigenic Specificity | FXN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: FXN antibody detects endogenous levels of total FXN. Description: FXN, also named as FRDA, X25, m81-FXN, d-FXN, m78-FXN and i-FXN, belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. The mature form of FXN is 14kd or 18kd.Function: Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved i |
Immunogen | Immunogen: A synthesized peptide derived from human FXN Subcellular Location: Cytoplasm. Mitochondrion. PubMed:18725397 reports localization exclusively in mitochondria. Tissue Specificity: Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts. Predicted Cross Reactivity: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken Similarity: Zebrafish (91%), Bovine (92%), Horse (100%), Sheep (92%), Rabbit (100%), Dog (100%), Chicken (92%) |
Other Names | [CyaY; d-FXN; FA; FARR; Frataxin mature form; Frataxin(81-210); FRDA; FRDA_HUMAN; Friedreich ataxia protein; Fxn; i-FXN; m56-FXN; m78-FXN; m81-FXN; MGC57199; X25] |
Gene, Accession # | [FXN], Gene ID: 2395, NCBI: NP_000135.2, UniProt: Q16595 |
Catalog # | MBS9607246 |
Price | $240, $280 |
Order / More Info | FXN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |