SMURF 2/SMURF2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SMURF 2/SMURF2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin, Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), Direct ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: No cross reactivity with other proteins. Description: Rabbit IgG polyclonal antibody for SMURF 2/SMURF2 detection. Tested with WB, IHC-P, IHC-F, ICC, FCM, Direct ELISA in Human; Mouse; Rat.Background: E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. The SMURF2 gene is mapped to chromosome 17q22-q23 based on sequence similarity between the SMURF2 sequence and a genomic contig. SMURF2 is a HECT domain E3 ubiquitin ligase involved in degradation of SMADs, TGF-beta receptor (TGFBR), and other substrates. It also functions in regulation of neuronal and planar cell polarity, induction of senescence, and tumor suppression. |
| Immunogen | Immunogen: E Coli-derived human SMURF 2/SMURF2 recombinant protein (Position: W303-Q387). Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. Relevant Detection Systems: Relevant Detection Systems: We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (MBS176453) for IHC(P), IHC(F) and ICC. |
| Other Names | [E3 ubiquitin-protein ligase SMURF2; SMAD specific E3 ubiquitin protein ligase 2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2] |
| Gene, Accession # | [SMURF2], Gene ID: 64750, NCBI: NP_073576, UniProt: Q9HAU4 |
| Catalog # | MBS1752491 |
| Price | $280 |
| Order / More Info | SMURF 2/SMURF2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2. 2. Blank, M., Tang, Y., Yamashita, M., Burkett, S. S., Cheng, S. Y., Zhang, Y. E. A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nature Med. 18: 227-234, 2012. 3. Lin X, Liang M, Feng XH (Nov 2000). Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. The Journal of Biological Chemistry 275(47): 36818-22. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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