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Antigenic Specificity | TIM-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 16 amino acid peptide from near the center of human TIM-1. |
Other Names | [T cell immunoglobulin and mucin domain containing protein 1, Hepatitis A virus cellular receptor 1, HAVcr-1, Kim-1] |
Gene, Accession # | [TIM-1], Gene ID: 26762, NCBI: NP_036338 |
Catalog # | MBS9414514 |
Price | $320 |
Order / More Info | TIM-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |