Desmin (Paired T76/77), Non-phospho Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Desmin (Paired T76/77), Non-phospho |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | Size: 100 ug/200 ul |
| Applications | ELISA, Western Blot, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody recognizes ~55 kDa of human Desmin protein without phosphorylated Thr76/Thr77). It does not recognize phosphorylated peptides confirmed by dot blot. The other species are not tested. Desmin is a major intermediate filament protein found exclusively in striated (skeletal or cardiac) muscle tissue. It belongs to a large family of class III intermediate filament protein, the main intermediate filamentin mature skeletal, cardiac and smooth muscle cells. Mutations in the gene encoding desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. PKC (Protein Kinase C) and cAMP-dependent protein kinase can induce disassembly of the desmin filaments by phosphorylating |
| Immunogen | Antigen Preparation: A synthetic peptide corresponding to the N-terminus surrounding Threonine (Thr76/Thr77) without phosphorylation of human Desmin. |
| Other Names | [Rabbit -Desmin (Paired T76/77); Non-phosphospecific; Desmin], [DES; DES; CSM1; CSM2; CMD1I; FLJ12025; FLJ39719; FLJ41013; FLJ41793] |
| Gene, Accession # | [Desmin (Paired T76/77)], Gene ID: 1674, NCBI: NP_001918.3, UniProt: P17661 |
| Catalog # | MBS462177 |
| Price | $265 |
| Order / More Info | Desmin (Paired T76/77), Non-phospho Antibody from MYBIOSOURCE INC. |
| Product Specific References | Xupei Huang, et al. Protein Kinase C-Mediated Desmin Phosphorylation Is Related to Myofibril Disarray in Cardiomyopathic Hamster Heart. Experimental Biology and Medicine 227:1039-1046 (2002). S Kitamura, et al. Protein kinase C phosphorylation of desmin at four serine residues within the non-alphahelical head domain. J. Biol. Chem., Vol. 264 (10), 5674-5678 (1989). |
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