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Antigenic Specificity | Phospho-PAK4 (pSer474) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse, bovine, chicken, dog |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunoprecipitation |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes the phosphorylated peptide only. It recognizes PAK4 protein at a phosphorylation site of Serine 474 (~68kDa), or serine 602 of PAK5 (~90kDa) or Serine 560 of PAK6 (~80 kDa). It does not cross react to other PAK1, PAK2 or PAK3. This antibody reacts with human, rat and mouse. The other species are not tested. p21-activated protein kinase (PAK) serine/threonine kinases are important effectors of Rho family GTPases and have been implicated in the regulation of cell morphology and motility, as well as in cell transformation. The phosphorylation of serine 474 as the likely autophosphorylation site in the kinase domain of PAK4 occurs in vivo. PAK4 is frequently over-expressed in human tumor cell lines of various tissue ori |
Immunogen | Antigen Preparation: A synthetic peptide surrounding the epitope RKSLV-with a phosphorylation at Serine 474 of human PAK4. This sequence is also identical within human, rat, mouse, chicken, bovine and dog species. |
Other Names | n/a |
Gene, Accession # | [PAK4 (pS474)] |
Catalog # | MBS462102 |
Price | $285 |
Order / More Info | Phospho-PAK4 (pSer474) Antibody from MYBIOSOURCE INC. |
Product Specific References | Marinella G. Callow et al. Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines. (2002) J. Biol. Chem. 277 (1), 550-558. |