Edit |   |
---|---|
Antigenic Specificity | NEUROD1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: NEUROD1 antibody detects endogenous levels of total NEUROD1. Description: NeuroD is a member of the basic helix-loop-helix (bHLH) family of transcription factors. These proteins function by forming heterodimers with E-proteins and binding to the canonical E-box sequence CANNTG (1, 2). Neuronal activity results in CaMKII-mediated phosphorylation of NeuroD at Ser336, which is necessary for formation and growth of dendrites (3, 4). NeuroD is also phosphorylated at Ser274 though the results are context dependent as phosphorylation by Erk stimulates NeuroD activity in pancreatic beta-cells while phosphorylation by GSK-3beta inhibits NeuroD in neurons (3). NeuroD is crucially important in both the pancreas and developing nervous syst |
Immunogen | Immunogen: A synthesized peptide derived from human NEUROD1 Subcellular Location: Cytoplasm. Nucleus. Predicted Cross Reactivity: Pig, Bovine, Horse, Chicken Similarity: Pig (100%), Bovine (100%), Horse (100%), Chicken (100%) |
Other Names | [atonal; basic helix loop helix transcription factor; BETA 2; Beta cell E box transactivator 2; BETA2; BHF 1; BHF1; bHLHa3; class A basic helix loop helix protein 3; Class A basic helix-loop-helix protein 3; MODY 6; MODY6; NDF1_HUMAN; NeuroD; NeuroD1; Neurogenic differentiation 1; Neurogenic differentiation factor 1; neurogenic helix loop helix protein NEUROD; Neuronal differentiation 1] |
Gene, Accession # | [NEUROD1], Gene ID: 4760, NCBI: NP_002491.2, UniProt: Q13562 |
Catalog # | MBS9606940 |
Price | $240, $280 |
Order / More Info | NEUROD1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |