Human TICAM2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human TICAM2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | n/a |
| Applications | ELISA (EIA), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TIC |
| Immunogen | Immunogen: Recombinant human TIR domain-containing adapter molecule 2 protein (1-235aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34743 / sc-34744 / sc-34748 / sc-67061 |
| Other Names | [TICAM-2;Putative NF-kappa-B-activating protein 502;TRIF-related adapter molecule;Toll-like receptor adaptor protein 3;Toll/interleukin-1 receptor domain-containing protein;MyD88-4;TICAM2;TIRAP3; TIRP; TRAM], [TMED7-TICAM2; TICAM2; TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4] |
| Gene, Accession # | [TICAM2], Gene ID: 100302736, NCBI: NP_001157940.1, UniProt: Q86XR7 |
| Catalog # | MBS1492274 |
| Price | $120, $160 |
| Order / More Info | Human TICAM2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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