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Antigenic Specificity | Human CEACAM1 |
Clone | [GM-8G5] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), CELISA and Immunohistology on cryosections |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: anti-human CEACAM1 (biliary glycoprotein I, BGP/CD66a). Background: CEACAM1 (BGP/CD66a) is a transmembrane glycoprotein which belongs to the carcinoembryonic antigen (CEA) gene family (1,2). It is expressed on cells of epithelial and myeloid origin and mediates homophilic intercellular interactions that influence cellular growth, immune cell activation, and tissue morphogenesis. CEACAM1 is a putative tumour suppressor based on diminished expression in some aggressive types of cancer cells (3). The anti-tumour effect may be due to inhibition of tumour angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells (4). Like all members of the CEACAM family, it consists of a single N domain, with structu |
Immunogen | Immunogen: Immunogen: cDNA |
Other Names | [CD66a; BGP; biliary glycoprotein I], [CEACAM1; CEACAM1; BGP; BGP1; BGPI; BGP; BGP1; BGP-1] |
Gene, Accession # | Gene ID: 634, NCBI: NP_001020083.1, UniProt: P13688 |
Catalog # | MBS468039 |
Price | $505 |
Order / More Info | Human CEACAM1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Zimmermann W (2002). Carcinoembryonic antigen. In Wiley Encyclopedia of Molecular Medicine(T. Creighton, ed.), John Wiley & Sons Inc., New York, USA, pp. 459-462.Hammarstrom S (1999). The carcinoembryonic antigen (CEA) family: structures, suggestedfunctions and expression in normal and malignant tissues. Semin. Cancer Biol. 9, 67-81.Luo W, Tapolsky M, Early K, Wood CG, Wilson DR, Logothetis CJ, Lin SH (1999). Tumorsuppressiveactivity of CD66a in prostate cancer. Cancer Gene Ther. 6(4): 313-21.Tilki D, Irmak S, Oliveira-Ferrer L, Hauschild J, Miethe K, Atakaya H, Hammerer P, FriedrichMG, Schuch G, Galalae R, Stief CG, Kilic E, Huland H, Ergun S (2006). CEA-related celladhesion molecule-1 is involved in angiogenic switch in prostate cancer. Oncogene 25(36):4965-74 |