HSP90B1 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | HSP90B1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Secretory proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. The ER contains a pool of molecular chaperones, including Grp94, to help proteins fold properly. Grp94 is a glucose-regulated protein (1) with sequence homology to Hsp90 (2). In addition to its role to help some secretory proteins fold to their correct conformation (3), studies suggest that Grp94 derived from cancer cells also induces anti-tumor immune responses in mouse tumor models (4, 5). One reason for this tumor immunogenicity is that Grp94 binds to the peptides from proteins in cancer cells and can therefore present these |
| Immunogen | Immunogen: Recombinant protein of human HSP90B1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [HSP90B1; ECGP; GP96; GRP94; TRA1] |
| Gene, Accession # | [HSP90B1], Gene ID: 7184, NCBI: NP_003290.1, UniProt: P14625 |
| Catalog # | MBS8502687 |
| Price | $310 |
| Order / More Info | HSP90B1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Lee, A.S. et al. (1981) Proc. Natl. Acad. Sci. USA 78, 4922-4925. 2. Sorger, P.K. and Pelham, H.R. (1987) J. Mol. Biol. 194, 341-344. 3. Argon, Y. and Simen, B.B. (1999) Semin. Cell Dev. Biol. 10, 495-505. 4. Blachere, N.E. et al. (1997) J. Exp. Med. 186, 1315-1322. 5. Tamura, Y. et al. (1997) Science 278, 117-120. 6. Schild, H. and Rammensee, H.G. (2000) Nat. Immunol. 1, 100-101. 7. Singh-Jasuja, H. et al. (2000) Eur. J. Immunol. 30, 2211-2215. 8. Nicchitta, C.V. et al. (2004) Cell Stress Chaperones 9, 325-331. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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