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Antigenic Specificity | FOXA1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated gene |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 263-472 of human FOXA1 (NP 004487.2). |
Other Names | [HNF3A; TCF3A] |
Gene, Accession # | [FOXA1], Gene ID: 3169, NCBI: NP_004487, UniProt: P55317 |
Catalog # | MBS8549834 |
Price | $280 |
Order / More Info | FOXA1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |