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Antigenic Specificity | BAG1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human BAG1 (NP 001165886.1). |
Other Names | [HAP; BAG-1; RAP46] |
Gene, Accession # | [BAG1], Gene ID: 573, NCBI: NP_001165886.1, UniProt: Q99933 |
Catalog # | MBS8544235 |
Price | $280 |
Order / More Info | BAG1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |