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Antigenic Specificity | LAPTM4B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: LAPTM4B antibody detects endogenous levels of LAPTM4B. Function: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4, 5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in |
Immunogen | Immunogen: A synthesized peptide derived from human LAPTM4B. Subcellular Location: Endomembrane System; Multipass Membrane Protein. |
Other Names | [LAPTM4beta; LC27; Lysosomal associated protein transmembrane 4 beta; Lysosomal associated transmembrane protein 4 beta; Lysosomal associated transmembrane protein 4B; Lysosomal protein transmembrane 4 beta] |
Gene, Accession # | [LAPTM4B], Gene ID: 55353, NCBI: NP_060877.3, UniProt: Q86VI4 |
Catalog # | MBS9603644 |
Price | $240, $280 |
Order / More Info | LAPTM4B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |