DNAJC3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DNAJC3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: DNAJC3 antibody detects endogenous levels of total DNAJC3. Function: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.Subunit Structure: Interacts with EIF2AK4/GCN2; this interaction occurs under endoplasmic |
| Immunogen | Immunogen: A synthesized peptide derived from human DNAJC3 Subcellular Location: Endoplasmic Reticulum. Tissue Specificity: Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus Similarity: Pig (100%), Bovine (92%), Horse (100%), Sheep (100%), Dog (100%), Chicken (91%), Xenopus (91%) |
| Other Names | [DnaJ (Hsp40) homolog subfamily C member 3; DnaJ homolog subfamily C member 3; DNAJC3; DNJC3_HUMAN; double-stranded RNA-activated protein kinase inhibitor; Endoplasmic reticulum DnaJ protein 6; ERdj6; HP58; Interferon induced, double stranded RNA activated protein kinase inhibitor; Interferon-induced; P58; p58 ipk; P58IPK; PRKRI; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58; Protein kinase interferon inducible double stranded RNA dependent inhibitor] |
| Gene, Accession # | [DNAJC3], Gene ID: 5611, NCBI: NP_006251.1, UniProt: Q13217 |
| Catalog # | MBS9608267 |
| Price | $240, $280 |
| Order / More Info | DNAJC3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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