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Antigenic Specificity | PTPN11 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 514-593 of human PTPN11 (NP 002825.3). |
Other Names | [CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3] |
Gene, Accession # | [PTPN11], Gene ID: 5781, NCBI: NP_002825.3, UniProt: Q06124 |
Catalog # | MBS8545066 |
Price | $280 |
Order / More Info | PTPN11 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |