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Antigenic Specificity | SETD8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. |
Immunogen | Immunogen: Recombinant protein of human SETD8 |
Other Names | [KMT5A; PR-Set7; SET07; SET8] |
Gene, Accession # | [SETD8], Gene ID: 387893, NCBI: NP_001311433.1, UniProt: Q9NQR1 |
Catalog # | MBS8500566 |
Price | $310 |
Order / More Info | SETD8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |