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Antigenic Specificity | JIP2/IB2 |
Clone | [S135-37] |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG1 |
Format | APC-Cy7 conjugate |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~>100 kDa. Does not cross-react with JIP-1/IB-1. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. It is expressed mainly in the cerebellum, pituitary gland, occipital lobe, and the amygdala of the brain, but also in the pancreas, including insulin-secreting cells. |
Immunogen | Immunogen: Fusion protein amino acids 226-421 of mouse JIP-2/IB-2. Rat: 94% identity (127/135 amino acids identical). Human: 86% identity (173/200 amino acids identical) >50% identity with JIP-1. |
Other Names | [Mouse Mouse JIP2/IB2 IgG1; JIP2/IB2 : APC/Cy7; MAPK8IP2; C jun amino terminal kinase interacting protein 2; C-jun-amino-terminal kinase-interacting protein 2; Homologous to mouse JIP 1; IB 2; IB-2; IB2; Islet brain 2; Islet-brain-2; JIP 2; JIP-2; JIP2; JNK interacting protein 2; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; MAPK8IP2; Mitogen activated protein kinase 8 interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2; PRKM8 interacting protein like; PRKM8IPL] |
Gene, Accession # | [JIP2/IB2], Gene ID: 60597, NCBI: NP_068740.3, UniProt: Q9ERE9 |
Catalog # | MBS8003472 |
Price | $510 |
Order / More Info | JIP2/IB2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |