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Antigenic Specificity | AURKA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total AURKA protein. Aurora A (AIK) is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines (1-3). Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis (4). The closely-related kinase Aurora B (AIM1) has been implicated in multiple mitotic events (5), and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization (6). |
Immunogen | Immunogen Type: Peptide Immunogen Description: A synthetic peptide of human AURKA. |
Other Names | [AIK; ARK1; AURA; AURORA2; BTAK] |
Gene, Accession # | [AURKA], Gene ID: 6790, NCBI: NP_003591.2, UniProt: O14965 |
Catalog # | MBS9412779 |
Price | $255 |
Order / More Info | AURKA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |