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Antigenic Specificity | Phospho-TNFR (S274) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This TNFR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S274 of human TNFR. A member of the TNF-receptor superfamily, this protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant pe |
Immunogen | n/a |
Other Names | [Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD120a; Tumor necrosis factor receptor superfamily member 1A; membrane form; Tumor necrosis factor-binding protein 1; TBPI; TNFRSF1A; TNFAR; TNFR1] |
Gene, Accession # | [TNFRSF1A], Gene ID: 7132, NCBI: NP_001056.1, UniProt: P19438 |
Catalog # | MBS9211248 |
Price | $165, $370 |
Order / More Info | Phospho-TNFR (S274) Antibody from MYBIOSOURCE INC. |
Product Specific References | Kuo, N.W., et al., Invest. Ophthalmol. Vis. Sci. 46(5):1565-1571 (2005). Siebert, S., et al., Arthritis Rheum. 52(4):1287-1292 (2005). Spahr, L., et al., J. Hepatol. 41(2):229-234 (2004). Wang, W.H., et al., Mol. Cell. Biol. 24(23):10352-10365 (2004). Tashiro, H., et al., Transpl. Int. 17(10):626-633 (2004). |