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Antigenic Specificity | HIRA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.4 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total HIRA protein. This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells.It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. |
Immunogen | Immunogen: Synthetic peptide of human HIRA |
Other Names | [TUP1; DGCR1; TUPLE1] |
Gene, Accession # | [HIRA], Gene ID: 7290, NCBI: NP_003316.3, UniProt: P54198 |
Catalog # | MBS9416406 |
Price | $255 |
Order / More Info | HIRA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |