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Antigenic Specificity | Collagen IV |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total Collagen IV protein. Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.Mary K. Chelberg, Cancer Res., Sep 1989; 49: 4796 - 4802.Patricia L. Graham, J. Cell Biol., Jun 1997; 137: 1171.PJ Lein, J. Cel |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from human Collagen IV. |
Other Names | [COL4A1 NC1 domain; COLLAGEN OF BASEMENT MEMBRANE; ALPHA-1 CHAIN ARRESTEN; alpha 1 type IV collagen preproprotein; collagen IV alpha-1 polypeptide] |
Gene, Accession # | Gene ID: 1282, NCBI: NP_001290039.1, UniProt: P02462 |
Catalog # | MBS9407044 |
Price | $200, $255 |
Order / More Info | Collagen IV Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |