Human cdc25B Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Human cdc25B antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Human cdc25B |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis (1). cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint (2). When phosphorylated at Ser216, cdc25C binds to members of the 14-3-3 family of proteins, sequestering cdc25C in the cytoplasm preventing premature mitosis (3). The checkpoint kinases Chk1 and Chk2 phosphorylate cdc25C at Ser216 in response to DNA damage (4,5). The major 14-3-3 binding sites of cdc25B are Ser309 and Ser361, both of which can be phosphorylated by p38 in response to ultraviolet radiation (6). |
| Immunogen | Immunogen: A Fusion protein of human cdc25B |
| Other Names | [Cdc25B Rabbit pab], [CDC25B; CDC25HU2; M phase inducer phosphatase 2] |
| Gene, Accession # | [cdc25B], Gene ID: 994, NCBI: NP_004349.1, UniProt: P30305 |
| Catalog # | MBS126110 |
| Price | $200, $275, $430 |
| Order / More Info | Human cdc25B Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Jessus, C. and Ozon, R. (1995) Prog. Cell Cycle Res. 1, 215-228. 2. Peng, C.Y. et al. (1997) Science 277, 1501-1505. 3. Kumagai, A. and Dunphy, W.G. (1999) Genes Dev. 13, 1067-1072. 4. Blasina, A. et al. (1999) Curr. Biol. 9, 1-10. 5. Furnari, B. et al. (1999) Mol. Biol. Cell 10, 833-845. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies