P53 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | P53 |
| Clone | [Bp53.12] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC), Immunocytochemistry (IHC), Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Bp53.12 reacts with a denatuRation-resistant epitope of p53. This antibody is specific for Human p53 and recognizes amino acid sequence 16-25. AlteRations of the p53 tumor suppressor gene are considered critical events in multistage carcinogenesis of a wide range of Human cancers. The mutations found in sporadic cancer are commonly mis-sense mutations that inactivate the tumor suppressor activity of p53. These mutant proteins are much more stable than the normal p53 protein, frequently adopt an altered conformation and accumulate within the malignant cells. |
| Immunogen | Source Note: Bp53.12 is a Mouse monoclonal IgG2a antibody derived by fusion of X63 Ag8.653 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with recombinant Human wild-type p53 protein. |
| Other Names | [P53; Cellular tumor antigen p53; cellular tumor antigen p53; antigen NY-CO-13; OTTHUMP00000221333; OTTHUMP00000221334; OTTHUMP00000221336; OTTHUMP00000221337; OTTHUMP00000221340; phosphoprotein p53; p53 tumor suppressor; transformation-related protein 53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53], [TP53; TP53; P53; LFS1; TRP53; FLJ92943; P53] |
| Gene, Accession # | Gene ID: 7157, UniProt: P04637 |
| Catalog # | MBS570138 |
| Price | $415 |
| Order / More Info | P53 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Bartek, J., Bartkova, J., Vojtesek, B., Staskova, Z., Lukas, J., Rejthar, A., Kovarik, J., Midgley, C. A., Gannon, J. V., and Lane, D. P. (1991). Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of Human malignancies. Oncogene 6, 1699-1703. Bartek, J., Bartkova, J., Lukas, J., Staskova, Z., Vojtesek, B., and Lane, D. P. (1993). Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies. J Pathol 169, 27-34. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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