LIN28B Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | LIN28B |
| Clone | [1832CT281.64.17.75] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1,k |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | 0.5mg/mL |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This LIN28B antibody is generated from a mouse immunized with a recombinant protein of human LIN28B. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when over |
| Immunogen | n/a |
| Other Names | [Protein lin-28 homolog B; Lin-28B; LIN28B; CSDD2] |
| Gene, Accession # | [LIN28B], Gene ID: 389421, NCBI: NP_001004317.1, UniProt: Q6ZN17 |
| Catalog # | MBS9230988 |
| Price | $165, $370 |
| Order / More Info | LIN28B Antibody from MYBIOSOURCE INC. |
| Product Specific References | Moss E.G.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45 (2004). Mungall A.J.,et al.Nature 425:805-811 (2003). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Guo Y.,et al.Gene 384:51-61 (2006). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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