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Antigenic Specificity | CD40/TNFRSF5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 5(CD40) detection. Background: CD40 is a cell surface receptor that is expressed on the surface of all mature B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. It is a member of the tumor necrosis factor (TNF) receptor superfamily and is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin. |
Immunogen | Immunogen: E. coli-derived human CD40/TNFRSF5 recombinant protein (Position: E21-R193). Human CD40/TNFRSF5 shares 60.2% amino acid (aa) sequence identity with mouse CD40/TNFRSF5. |
Other Names | [B cell associated molecule CD40; B cell surface antigen CD40; B-cell surface antigen CD40; Bp50; CD40 antigen; CD40 molecule; CD40 protein; CD40 type II isoform; CD40L receptor; CDw40; TNFRSF5; TNR5; GP39; HIGM1; P25942; Tumor necrosis factor receptor superfamily member 5; CD40 molecule, TNF receptor superfamily member 5], [CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5] |
Gene, Accession # | [CD40], Gene ID: 958, NCBI: NP_001241.1, UniProt: P25942 |
Catalog # | MBS178807 |
Price | $280 |
Order / More Info | CD40/TNFRSF5 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Clark, E. A. : CD40: a cytokine receptor in search of a ligand. Tissue Antigens 35: 33-36, 1990.2. Harding, S. A.; Sarma, J.; Josephs, D. H.; Cruden, N. L.; Din, J. N.; Twomey, P. J.; Fox, K. A. A.; Newby, D. E. : Upregulation of the CD40/CD40 ligand dyad and platelet-monocyte aggregation in cigarette smokers. Circulation 109: 1926-1929, 2004.3. Kato, K.; Cantwell, M. J.; Sharma, S.; Kipps, T. J. : Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. J. Clin. Invest. 101: 1133-1141, 1998.4. Stamenkovic, I.; Clark, E. A.; Seed, B. : A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8: 1403-1410, 1989.5. van Kooten, C.; Banchereau, J. : CD40-CD40 ligand. J. Leuko. Biol. 67: 2-17, 2000. |