CD11a (activitor) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD11a (activitor) |
| Clone | [NKI(SPV)-L16] |
| Host Species | Mouse (Balb/c) |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody recognizes an activation epitope of CD11a and has been essential to define inside-out signaling of intergrin. Homotypic cell aggregate formation is stimulated (see also Background). Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a Human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed |
| Immunogen | Source Note: The antibody was raised by immunization of Balb/c mice with monocytes. The unique activation dependent epitope of the SPV-L16 antibody on the a-chain of LFA-1 is relatively insensitive to trypsin treatment and thus most likely loCated close to the transmembrane segment of the protein. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS570272 |
| Price | $415 |
| Order / More Info | CD11a (activitor) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Keizer GD, Visser W, Vliem M, Figdor CG. A monoclonal antibody (NKI-L16) directed anti a unique epitope on the alpha chain of Human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions. J. Immunol. 140: 1393-1400, 1988. Van Kooyk Y, Weder P, Hogervorst F, Verhoeven AJ, van Seventer G, te Velde AA, Borst J, Keizer GD, Figdor CG. Activation of LFA-1 through a Ca2( )-dependent epitope stimulates lymphocyte adhesion. J Cell Biol. 112: 345-54, 1991. Van Kooyk Y, van de Wiel-van Kemenade P, Weder P, Kuijpers TW, Figdor CG. Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature. 342:811-813, 1989. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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