n-Myc Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | n-Myc |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for N-myc proto-oncogene protein(MYCN) detection. Tested with WB in Human;Rat. Background: N-myc proto-oncogene protein, also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene. This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. And this protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human n-Myc (428-464aa EYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC), different from the related mouse and rat sequences by two amino acids. Ig Type: Rabbit IgG |
| Other Names | [N-myc proto-oncogene protein; bHLHe37; Class E basic helix-loop-helix protein 37; MODED; mycn; MYCN_HUMAN; N myc; N myc proto oncogene protein; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene; Neuroblastoma MYC oncogene; NMYC; NMYC proto oncogene protein; ODED; Oncogene NMYC; pp65/67; v myc avian myelocytomatosis viral related oncogene neuroblastoma derived; v myc myelocytomatosis viral related oncogene neuroblastoma derived; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog], [MYCN; MYCN; NMYC; ODED; MODED; N-myc; bHLHe37; BHLHE37; NMYC; bHLHe37] |
| Gene, Accession # | [n-Myc], Gene ID: 4613, NCBI: NP_001280157.1, UniProt: P04198 |
| Catalog # | MBS177938 |
| Price | $280 |
| Order / More Info | n-Myc Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Armstrong BC, Krystal GW (1992). Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.. Cell Growth Differ. 3 (6): 385-90. 2. Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas. Nat. Genet. 4 (2): 191-4. 3. Knoepfler PS, Cheng PF, Eisenman RN (2002). N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.. Genes Dev. 16 (20): 2699-712. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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