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Antigenic Specificity | TLR4/MD-2, Human |
Clone | 7E3 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | fluorescein (FITC) conjugate |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: The monoclonal antibody 7E3 reacts with the Toll-like receptor 4 (TLR4, CD284)/MD-2 complex. TLRs belong to a family of proteins that specifically recognizes and senses microbial products. They are highly conserved throughout evolution and act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. MD-2 exists as a cell surface protein in association with TLR4. It also exists as secreted forms consisting of MD-2 monomers and multimers (sMD-2). Circulating sMD-2 is mainly present as a doublet of ~20 and 25 kD, representing differentially gly |
Immunogen | Immunogen: TLR4/MD-2 expressing CHO cells/ chimeric TLR4/MD-2 fusion protein |
Other Names | n/a |
Gene, Accession # | [TLR4/MD-2] |
Catalog # | MBS584320 |
Price | $535 |
Order / More Info | TLR4/MD-2, Human Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |