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Antigenic Specificity | flip (IN) (I-flICE) (flICE Inhibitory Protein) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively1,2. The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and ?10, and potently inhibits apoptosis induced by all known |
Immunogen | Immunogen: Synthetic peptide corresponding to amino acids 447 to 464 of the C-terminal of the human FLIP /FLIPL form. |
Other Names | [Casper; I-FLICE; FLAME-1; CASH; CLARP C-terminal], [Casp8ap2; Casp8ap2; FLASH; AA387232; mKIAA1315; D4Ertd659e; Flash] |
Gene, Accession # | Gene ID: 26885, NCBI: NP_001116450.1, UniProt: Q9WUF3 |
Catalog # | MBS395728 |
Price | $510 |
Order / More Info | flip (IN) (I-flICE) (flICE Inhibitory Protein) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |