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Antigenic Specificity | Human NCSTN |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. NCT controls cell death via phosphoinositide 3-kinase/Akt and p53-dependent pathways and that this function remains independent of the activity and molecular integrity of the gamma-secretase complexes. Increasing evidences have shown that Nicastrin/NCSTN plays a crucial role in gamma-cleavage of the amyloid precursor protein (APP). The glycoprotein Nicastrin is an essential component of the gamma-secretase complex, a high molecular weight complex which also co |
Immunogen | Immunogen: Recombinant Human Nicastrin/NCSTN Protein Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human Nicastrin/NCSTN (rh Nicastrin/NCSTN; NP 056146.1; Met 1-Glu 669). |
Other Names | [nicastrin isoform 2; Nicastrin; nicastrin; nicastrin] |
Gene, Accession # | [NCSTN ], Gene ID: 23385 |
Catalog # | MBS2544189 |
Price | $215, $330, $500 |
Order / More Info | Human NCSTN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |