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Antigenic Specificity | Human Poly(A)-specific ribonuclease PARN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | caprylic acid ammonium sulfate precipitate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich ele |
Immunogen | Immunogen: Recombinant human Poly(A)-specific ribonuclease PARN protein |
Other Names | [PAM16 MAGMAS; TIM16; TIMM16 CGI-136] |
Gene, Accession # | Gene ID: 5073, NCBI: NP_001127949.1, UniProt: O95453 |
Catalog # | MBS7000840 |
Price | $160, $235 |
Order / More Info | Human Poly(A)-specific ribonuclease PARN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |