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Antigenic Specificity | Dnmt3a |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
Immunogen | Immunogen: A synthesized peptide derived from human Dnmt3a. Subcellular Localization: Nucleus. Cytoplasm. Accumulates in the major satellite repeats at pericentric heterochromatin. Tissue Specificity: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. |
Other Names | [DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; 2.1.1.37; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA; DNMT3A], [DNMT3A; DNMT3A; TBRS; DNMT3A2; M.HsaIIIA; Dnmt3a; DNA MTase HsaIIIA; M.HsaIIIA] |
Gene, Accession # | [Dnmt3a], Gene ID: 1788, NCBI: NP_001307821.1, UniProt: Q9Y6K1 |
Catalog # | MBS179134 |
Price | $160, $340, $340 |
Order / More Info | Dnmt3a Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |